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Kleine-Levin syndrome (recurrent hypersomnia)

Clinical features of Kleine-Levin's sydrome (recurrent hypersomnia)
Drowsiness.
Depressed mood.
Excessive intake of food.
Hypersexuality. Altered sexual behavior, compulsive sexual activity.
Aggressiveness.
Apathy.

It is a very rare entity, which presents annual episodes of hypersomnia, eating disorders and neuropsychiatric symptoms. The duration of the episodes ranges from a few days to a month. During these intense periods of sleep, which can be hard days or weeks, subjects suffer from an uncontrollable urge to sleep, that lead them go to bed 18 hours a day. This uncommon condition of daytime sleepiness can be completed with the appearance of isolation from other symptoms such as hyperphagia, polyphagia, aggression, sexual disinhibition, irritability or unjustified apathy. A review study published by Orlosky assessed the syndrome symptoms by analyzing 33 cases to narrow the complex clinical picture. The most common abnormalities founded were confusion (73%), irritability (58%), amnesia (39%), hallucinations (30%), lethargy (24%), depression (21%) and sexual disinhibition (18%). Because of this complex symptomatology it is usually concluded with an equivocal differential diagnosis of psychiatric disorders usually influenced by frequent mood changes, which are characteristic of the disease. The days of normal sleep patterns occur in structure and polysomnographic data recorded occasionally decreased slow-wave sleep. The cases diagnosed just describe two hundred patients registered by a higher male prevalence among adolescents and young adults and in the case of women associated with menstrual periods. SKL is generally considered a benign disease, that is not of prognostic unless serious commitment to impairment of normal life for the development of work or academic activities, that are suspended during seriously disrupting episodes in their lives. The behavior and health of patients event-free time can be completely normal.

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